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The purpose of this new codification is to ensure that the numbering / coding of ICH Guidelines is more logical, consistent and clear.Because the new system applies to existing as well as new ICH Guidelines a history box has been added to the beginning of all Guidelines to explain how the Guideline was developed and what is the latest version.Arrayed against strategies produced by various teams it won in two competitions.After the first competition, new strategies formulated specifically to combat tit-for-tat failed due to their negative interactions with each other; a successful strategy other than tit-for-tat would have had to be formulated with both tit-for-tat and itself in mind.On the other hand, if the other party competes, then the tit-for-tat strategy will lead the alternate party to compete as well.Ultimately, each action by the other member is countered with a matching response, competition with competition and cooperation with cooperation.

Finally, it is forgiving as it immediately produces cooperation should the competitor make a cooperative move.For implementation reasons, the Regulatory Authorities working within the ICH Regions may not have changed the codification retrospectively.Tit for tat is an English saying meaning "equivalent retaliation".Harmonisation achievements in the Quality area include pivotal milestones such as the conduct of stability studies, defining relevant thresholds for impurities testing and a more flexible approach to pharmaceutical quality based on Good Manufacturing Practice (GMP) risk management.ICH has produced a comprehensive set of safety Guidelines to uncover potential risks like carcinogenicity, genotoxicity and reprotoxicity.

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